A copycat killer who goes by the name “The Trickster” (guest star Devon Graye) starts setting off bombs in Central City.
As Zoe (Rachel Bilson) and Wade (Wilson Bethel) try to work out their issues, Zoe makes a life-changing decision and Wade does everything he can to make it happen before their baby is born.
Sam (Jared Padalecki) and Dean (Jensen Ackles) investigate a string of suicides committed by people with little in common other than the identical, grisly method of death – slow, self-administered disembowlment.
It’s celebration time as Diggle (David Ramsey) and Lyla (guest star Audrey Marie Anderson) get married.
When Catherine (Megan Follows) becomes suspicious that Mary (Adelaide Kane) and Condé (Sean Teale) are having an affair, Mary risks Catherine discovering just how deep her betrayal goes.
With the help of Bonnie (Kat Graham) and Kai (guest star Chris Wood), Damon (Ian Somerhalder) and Elena (Nina Dobrev) set forth a plan to rescue Damon’s mother Lily (guest star Annie Wersching), who is trapped in the 1903 prison world.
Despite Dean’s (Jensen Ackles) directive to forget about looking for a cure for the Mark of Cain, Sam (Jared Padalecki) continues to do research.
Still weighed down by his last meeting with Ra’s al Ghul (guest star Matt Nable), Oliver (Stephen Amell) returns home to find a new villain and his crew have started terrorizing Starling City – Michael Amar AKA Murmur (guest star Adrian Glynn McMorran), a man whose mouth has been sewn shut.
Jane (Gina Rodriguez) is feeling distant from Rafael (Justin Baldoni) so she focuses on her writing instead, but is stuck with a case of writers block.
Suspicious of where her true loyalties lie, Klaus (Joseph Morgan) invites Freya (guest star Riley Voelkel) to the compound in order to gain more insight into her past with Dahlia.