Desperate to find a way to vanquish Dahlia (guest star Claudia Black), Klaus (Joseph Morgan) soon finds himself face-to-face with another deadly threat – Mikael (guest star Sebastian Roché).
When Clive (Malcolm Goodwin) identifies a John Doe in the morgue as one of his former criminal contacts from his days on the vice squad, Liv (Rose McIver) is surprised that Clive is so quick to refuse her help in solving the murder.
When Eva Sinclair’s (guest star Maisie Richardson-Sellers) reemergence leaves Rebekah trapped and helpless, Klaus (Joseph Morgan) is forced to put aside his mistrust for Freya (guest star Riley Voelkel) in order to save Rebekah’s life.
When a crisis with the hotel overwhelms Rafael (Justin Baldoni), Jane (Gina Rodriguez) becomes concerned that he might not be as hands-on in fatherhood as she expected.
Sam (Jared Padalecki) and Castiel (Misha Collins) follow up on a lead about the Mark of Cain. Dean (Jensen Ackles) and Rowena (guest star Ruth Connell) meet.
During an attack on the mayor’s office, Ray (Brandon Routh) is critically injured.
As Liv (Rose McIver) and Detective Babineaux (Malcolm Goodwin) investigate a hit and run case, they discover the victim was a sociopathic hit man responsible for the murder of a tech entrepreneur, a case that Peyton (Aly Michalka) is prosecuting.
A copycat killer who goes by the name “The Trickster” (guest star Devon Graye) starts setting off bombs in Central City.
As Zoe (Rachel Bilson) and Wade (Wilson Bethel) try to work out their issues, Zoe makes a life-changing decision and Wade does everything he can to make it happen before their baby is born.
Sam (Jared Padalecki) and Dean (Jensen Ackles) investigate a string of suicides committed by people with little in common other than the identical, grisly method of death – slow, self-administered disembowlment.